Which layer of the skin is primarily responsible for sensation?

The dermis is primarily responsible for sensation due to its rich supply of nerve endings and sensory receptors. This layer houses various types of nerve endings, such as those that detect pain, temperature, and touch. These sensory organs send signals to the brain, allowing us to feel and respond to various stimuli.

In contrast, while the epidermis does contain some nerve endings, its main function is to provide a protective barrier as the outermost layer of skin. The hypodermis, which lies beneath the dermis, primarily serves to anchor the skin to underlying structures and store fat, rather than play a role in sensation. The subcutaneous layer similarly is not directly involved in sensory perception, focusing more on insulation and cushioning. Thus, the dermis stands out as the critical layer for the sensation due to its specialized sensory structures.